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June 13, 2019
E-cigarettes: The Basics, Use in Smoking Cessation, and the Adolescent Epidemic with Dr. Jonathan Winickoff
The rise in popularity of e-cigarettes in the last 5 years has changed the landscape and language surrounding nicotine delivery, smoking cessation, and adolescent substance use. In this episode of Curbside Consults, Dr. Jonathan Winickoff, Professor of Pediatrics at Mass General Hospital for Children and Director of Pediatric Research...
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May 30, 2019
Statistical Review – Composite Outcomes with Dr. Dave Harrington
Composite outcomes are frequently used as primary outcomes in randomized-controlled trials and observational studies. Why are they used? What are the limitations of their use? How are composite outcomes interpreted? Join us in this episode as Dr. David Harrington, statistical editor at the NEJM, helps breakdown composite outcomes.
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May 15, 2019
Infective Endocarditis with Dr. Henry Chambers
Infective endocarditis is a rare infection associated with a high mortality. Patients are often admitted for prolonged periods of time to receive antibiotics. The Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis or the POET trial asked the question whether patients with left sided infective endocarditis can be switched to oral...
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May 1, 2019
Statistical Review – Non-Inferiority Trials with Dr. Dave Harrington
Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, Dr Dave Harrington, our statistical editor here at the NEJM...
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April 17, 2019
Cardiovascular and Renal Outcomes in Type 2 Diabetes Medications with Dr. Marie McDonnell
The number of medications available to treat diabetes continues to increase. Recently, there has been widespread interest in two classes of medications, the SGLT2 inhibitors and the GLP1 agonists. They have created quite the splash with improvements in cardiovascular outcomes in patients with type 2 diabetes. In this podcast...
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March 29, 2019
Statistical Review – Power with Dr. Dave Harrington
Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re trying something new and bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, Dr Dave Harrington our statistical editor here...
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March 6, 2019
VTE Prophylaxis in Patients with Cancer with Dr. Jean Connors
Patients with cancer have a significantly higher risk of VTE. How do we assess risk for developing VTE in patients with cancer? Is there a role for primary VTE prophylaxis in cancer patients? If so what are our treatment options? On this podcast, our expert hematologist Dr Jean Connors delves into these questions and more.
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February 4, 2019
Statistical Review – Intention-to-Treat Versus Per-Protocol Analyses
Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re trying something new and bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, we discuss intention-to-treat and per-protocol...
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January 4, 2019
Worsening Asthma Symptoms and Preventing Asthma Exacerbations with Dr. Jeff Drazen
Winter is upon us and asthma exacerbations are on the rise. But how well can clinicians and patients predict and prevent these asthma exacerbations before they start? NEJM Editor-in-Chief and Pulmonologist Dr. Jeff Drazen discusses the challenge clinicians and patients face in the setting of worsening asthma symptoms, also known as...
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December 5, 2018
Statistical Review – P-values, Outcomes, Point-estimates and Confidence Intervals
Ever read a paper and feel a bit confused about all the statistical jargon and how to properly interpret the findings? At NEJM Resident 360, we’re trying something new and bringing you Statistical Review which aims to cover some key areas in research methodology and trial design. On this episode, we aim to cover basic ground over study...
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November 13, 2018
Acute MI and Cardiogenic Shock with Dr. John Jarcho
Every medical resident will need to manage acute myocardial infarction at some stage. But what makes a patient with acute MI and cardiogenic shock more of a challenge to manage? NEJM Deputy Editor and Cardiologist Dr John Jarcho discusses the details around the pathophysiology and management in these patients and the recent paper...
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October 19, 2018
Thyroid Disorders with Dr. Ole-Petter Hamnvik
There is a wide spectrum of disorders that affect the thyroid gland. Dr Hamnvik discusses the diagnostic testing of some of these common thyroid hormone disorders including hypothyroidism and hyperthyroidism and the evidence behind their management.
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August 22, 2018
Atrial Fibrillation with Dr. Eli Gelfand
Atrial fibrillation is the most commonly encountered, clinically significant arrhythmia. Dr Eli Gelfand discusses the key issues of atrial fibrillation management and takes a deep dive into the complexities and evidence that informs the pillars of atrial fibrillation management: anticoagulation, rate and rhythm control.
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June 28, 2018
Variceal and Lower GI Bleeding with Dr. Navin Kumar
Acute gastrointestinal bleeding is a broad topic with a range of manifestations, from scant hematochezia to the exsanguinating variceal hemorrhages. In this part 2 of 2 interviews, Dr. Navin Kumar discusses the management of variceal and lower GI bleeding and the evidence behind some of the major interventions...
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April 30, 2018
Community-Acquired Pneumonia with Dr. Anna Thorner
Community-acquired pneumonia is one of the most commonly encountered infections in the hospital setting. In this interview, Dr. Anna Thorner discusses the basics of diagnosing and treating pneumonia as well as delving into the roles of procalcitonin and glucocorticoids...
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March 14, 2018
Non-Variceal Upper GI Bleeding with Dr. Navin Kumar
Acute gastrointestinal bleeding is a broad topic with a range of manifestations, from scant hematochezia to the exsanguinating variceal hemorrhages. In this part 1 of 2 interviews, Dr. Navin Kumar discusses the management of acute non-variceal upper GI bleeding...
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March 1, 2018
IV Fluids and Glucocorticoids for Sepsis with Dr. Kathryn Hibbert
In this interview, Dr. Kathryn Hibbert reviews the biology underlying the effects of various fluids on the body and how sepsis disrupts the body’s natural response to corticosteroids. We also discuss the major points from these four new papers in the March 1, 2018 issue of NEJM and prior literature to get you up to speed on the evidence behind practice.
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February 2, 2018
ARDS with Dr. Patricia Kritek
Listen to an interview with Dr. Patricia Kritek in which we go beyond the sound bites about low tidal-volume ventilation, the importance of PEEP, neuromuscular blockade and prone positioning to highlight the key clinical trials and discuss in detail how these therapies may work.
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